Basic Concepts in Genetics and Linkage Analysis
نویسندگان
چکیده
This chapter explores the underpinnings for observational and experimental genetics. Concepts ranging from laws of Mendelian inheritance through molecular and chromosomal aspects of deoxyribonucleic acid (DNA) structure and function are defined; their ultimate utilization in linkage mapping of simple Mendelian disease and common and genetically complex disease is presented. The chapter concludes with clinical examples of the various types of DNA mutation and their implications for human disease.
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